Annals of Clinical Biochemistry > Volume 45, Number 1 > Pp. 93-95

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Short Report

Supraphysiological doses of intravenous PYY_3-36 cause nausea, but no additional reduction in food intake

Carel W le Roux, Cynthia M Borg, Kevin G Murphy, Royce P Vincent, Mohammad A Ghatei and Stephen R Bloom 

Department of Metabolic Medicine, 6th Floor Commonwealth Building, Hammersmith Hospital, Imperial College London, London W12 0NN, UK

Corresponding author: Prof Stephen R Bloom. Email: s.bloom{at}imperial.ac.uk

Background: Peptide YY (PYY_3-36) infused to levels within the physiological range reduces appetite and food intake in humans without nausea. However, PYY_3-36 has previously been shown to cause nausea at higher doses.

Methods: We studied the relationship of PYY_3-36, nausea and food intake in six volunteers, using three different PYY_3-36 preparations infused to achieve supraphysiological PYY plasma levels.

Results: Supraphysiological levels of PYY caused nausea in five subjects (P < 0.05). Although PYY_3-36 increased satiety (P < 0.05) and reduced food intake (P < 0.05), no greater enhancement of satiety or inhibition of food intake was observed compared with previous reports.

Conclusions: This study cautions against the use of supraphysiological doses of PYY_3-36 as it may increase nausea with no benefit in food reduction.

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