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Annals of Clinical Biochemistry

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Ann Clin Biochem 2008;45:96-98
doi:10.1258/acb.2007.007156
© 2008 Association for Clinical Biochemistry

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Short Report

Association of leprosy with HLA-DRB1 in an Argentinean population

Silvia García Borrás 1 , Carlos Cotorruelo 1 2, Liliana Racca 1, Mónica Recarte 3, Celeste Garcías 1, Claudia Biondi 1, Oscar Bottasso 4 and Amelia Racca 1


1 Laboratorio de Inmunohematología e Inmunogenética, Departamento de Bioquímica Clínica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario; 2 CONICET; 3 Servicio de Dermatología Hospital Carrasco de Rosario; 4 Instituto de Inmunología Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina


Corresponding author: Silvia García Borrás. Email: sigarcia{at}fbioyf.unr.edu.ar

Background: Previous studies have suggested an influence of HLA molecules on the regulation of the anti Mycobacterium leprae immune response.

Methods: DNA typing of HLA-DRB1 alleles in 71 leprosy patients and 81 healthy controls was performed. Genomic DNA was extracted from peripheral blood and used as a template to amplify the polymorphic second exon of the HLA-DRBl by the ploymerase chain reaction (PCR). PCR products were hybridized separately with sequence-specific oligonucleotides.

Results: DRB1*1401 and DRB1*1406 alleles were significantly more prevalent in leprosy patients, whereas a decreased frequency of DRB1*0808 and DRB1*1103 alleles was found, by comparison with the group control.

Conclusions: The HLA-DRB1 alleles could act alone or in combination with other genes to confer differential susceptibility and also protection to leprosy disease in endemic areas of the American continent.


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