Annals of Clinical Biochemistry > Volume 45, Number 2 > Pp. 167-169

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ankrah-Tetteh, T Articles by Swaminathan, R Search for Related Content PubMed PubMed Citation Social Bookmarking                      What's this?

Original Article

Intraindividual variation in serum thyroid hormones, parathyroid hormone and insulin-like growth factor-1

T Ankrah-Tetteh, S Wijeratne and R Swaminathan 

Department of Chemical Pathology, St Thomas' Hospital, 5th Floor, North Wing, Lambeth Palace Road, London SE1 7EH, UK

Corresponding author: Prof R Swaminathan. Email: r.swaminathan{at}gstt.nhs.uk

Background: Biological variation of an analyte is an important determinant of its usefulness. Intraindividual variation in serum thyroid hormones, parathyroid hormone (PTH) and insulin-like growth factor-1 (IGF-1) in healthy subjects was determined in this study.

Methods: Blood samples were taken at weekly intervals for six weeks from 10 healthy subjects and analysed for serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), PTH and IGF-1.

Results: Intraindividual variations for serum FT4 and FT3 were <5.0%, IGF-1 9.4% and TSH and PTH 25.1% and 25.9%, respectively. Index of individuality was lowest for FT4 (0.42) and FT3 (0.38), and highest for PTH (1.09).

Conclusion: Intraindividual variation for FT4, FT3 and IGF-1 are low.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. Waise and H. C Price The upper limit of the reference range for thyroid-stimulating hormone should not be confused with a cut-off to define subclinical hypothyroidism Ann Clin Biochem, March 1, 2009; 46(2): 93 - 98. [Abstract] [Full Text] [PDF]