Annals of Clinical Biochemistry > Volume 45, Number 2 > Pp. 167-169

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Original Article

Intraindividual variation in serum thyroid hormones, parathyroid hormone and insulin-like growth factor-1

T Ankrah-Tetteh, S Wijeratne and R Swaminathan 

Department of Chemical Pathology, St Thomas' Hospital, 5th Floor, North Wing, Lambeth Palace Road, London SE1 7EH, UK

Corresponding author: Prof R Swaminathan. Email: r.swaminathan{at}gstt.nhs.uk

Background: Biological variation of an analyte is an important determinant of its usefulness. Intraindividual variation in serum thyroid hormones, parathyroid hormone (PTH) and insulin-like growth factor-1 (IGF-1) in healthy subjects was determined in this study.

Methods: Blood samples were taken at weekly intervals for six weeks from 10 healthy subjects and analysed for serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), PTH and IGF-1.

Results: Intraindividual variations for serum FT4 and FT3 were <5.0%, IGF-1 9.4% and TSH and PTH 25.1% and 25.9%, respectively. Index of individuality was lowest for FT4 (0.42) and FT3 (0.38), and highest for PTH (1.09).

Conclusion: Intraindividual variation for FT4, FT3 and IGF-1 are low.

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