RSM logo
Annals of Clinical Biochemistry

Home Current issue Browse archive Alerts About the journal Feedback
 
Ann Clin Biochem 2008;45:213-214
doi:10.1258/acb.2007.007155
© 2008 Association for Clinical Biochemistry

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pozzetto, U.
Right arrow Articles by Facchiano, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Short Report

Balance of transforming growth factor-β1 and platelet-derived growth factor-BB is associated with kidney allograft rejection

Ubaldo Pozzetto 1 , Damiano Abeni 2, Franco Citterio 3, Marco Castagneto 3, Maurizio C Capogrossi 2 and Antonio Facchiano 2


1 Centro Shock, IASI–CNR, Largo Gemelli 8, 00168 Rome; 2 Istituto Dermopatico dell'Immacolata, IDI-IRCCS; 3 Dipartimento di Chirurgia, Università Cattolica Sacro Cuore, Rome, Italy


Corresponding author: Dr Ubaldo Pozzetto. Email: aldopozzetto{at}hotmail.com

Background: About 50% of kidney-transplant patients undergo organ rejection within 10 years. Chronic allograft nephropathy (CAN) represents the dominant cause of kidney transplant failure and accounts for 50–80% of graft loss in long-term surviving patients. CAN pathogenesis is multifactorial and not-completely elucidated; several reports indicate TGF-β1 and platelet-derived growth factor (PDGF)-BB expression in CAN suggesting a possible role of these factors in the allograft arteriosclerosis and graft failure.

Methods: We investigated the plasma expression concentrations of human growth factors with enzyme-linked immunosorbent assays and appropriate statistical analysis.

Results: We present evidences showing statistically significant association of CAN with a specific balance between TGF Beat1 and PDGF-BB plasma concentrations, in 129 kidney-transplant patients and 15 healthy controls. Odds ratios were computed to correlate expression-levels with CAN occurrence.

Conclusion: We believe these data may suggest a novel non-invasive method to identify early molecular markers of graft deterioration.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




Acute CT - A Primer of Emergency Imaging

 RSM Books - Beyond Thalidomide RSM Journals - Journal of Medical Biography