Annals of Clinical Biochemistry > Volume 45, Number 3 > Pp. 323-324

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Case Reports

A paediatric case of macro aspartate aminotransferase

Robert Lord¹, Michael Fahie-Wilson² and Sanjay Suri³

¹ Department of Clinical Biochemistry, Rotherham NHS Foundation Trust, Rotherham S60 2UD, UK; ² Biochemistry Department, Southend Hospital, Prittlewell Chase, Westcliff on Sea, Essex SS0 0RY, UK; ³ Department of Child Health, Rotherham NHS Foundation Trust, Rotherham S60 2UD, UK

Corresponding author: Dr R Lord. Email: robert.lord{at}rothgen.nhs.uk

Macroenzymes are enzymes in plasma that have a higher molecular mass than the corresponding enzyme normally present under (patho) physiological conditions. Macro species have been described for most routinely measured enzymes, but with only a few reports of macro species with aspartate aminotransferase (AST), and in particular very few reports in children and adolescents. Routine biochemical analysis in a 15-year-old girl presenting with lower back pain revealed an isolated raised AST as part of a liver function test profile. Polyethylene glycol precipitation and gel filtration chromatography showed this to be a macro species.

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