Annals of Clinical Biochemistry > Volume 45, Number 4 > Pp. 409-412

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Original Articles

Protein S-100 is present in extracerebral fluids before and after cardiac surgery in children

Nicole Nagdyman¹, Peter Ewert¹, Katharina Schmitt¹, Michael Hübler², Brigitte Stiller³, Christian Müller⁴ and Felix Berger⁵

¹ Department of Congenital Heart Disease; ² Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum; ³ Childrens University Hospital, 79106 Freiburg, Germany; ⁴ Institute of Laboratory Medicine; ⁵ Department of Pediatric Cardiology, Charité-Universitätsmedizin, 13353 Berlin, Germany

Corresponding author: Dr Nicole Nagdyman. Email: nagdyman{at}dhzb.de

Background: Protein S-100 is found in extracerebral sources. The aim of our study was to examine the content of protein S-100 in native pericardial fluid as well as in postoperative extracerebral fluids after cardiac surgery in children.

Methods: We conducted a prospective study in 90 children measuring protein S-100 concentration in pericardial fluid directly after opening the pericardial sac before starting with cardiac surgery. Postoperatively, we examined pleural, peritoneal and pericardial fluid.

Results: Pericardial fluid sampled directly after opening the pericardial sac has a protein S-100 content of 3.2 (1.3–5.4) µg/L. Postoperatively, protein S-100 content was 0.89 (0.56–2.6) µg/L in pleural effusion, 0.14 (0.1–1.1) µg/L in peritoneal fluid and 2.75 (2.2–24.4) µg/L in pericardial fluid. The protein S-100 concentration in pericardial fluid before and after cardiac operation did not differ significantly. Pericardial protein S-100 concentrations were significantly higher than pleural and peritoneal protein S-100 concentrations.

Conclusions: Protein S-100 is present in extracerebral fluids before and after cardiac surgery in children. The time point of fluid withdrawal after the operation did not influence the protein S-100 concentration.

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