Annals of Clinical Biochemistry > Volume 45, Number 6 > Pp. 610-611

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Case Reports

Acute intermittent porphyria presenting with a subarachnoid haemorrhage

Charles van Heyningen¹ and David M Simms²

¹ Clinical Laboratories, University Hospital Aintree, Liverpool L9 7AL; ² Chemical Pathology Department, Kingston Hospital, Kingston upon Thames KT2 7QB, UK

Corresponding author: Dr Charles van Heyningen. Email: charles.vanheyningen{at}aintree.nhs.uk

A 47-year-old man presented with abdominal pain, neck stiffness, severe transient hypertension and unusually dark urine. Cerebrospinal fluid investigations and angiography confirmed the diagnosis of a subarachnoid haemorrhage. Porphyrin studies on the patient and his family demonstrated that the family has acute intermittent porphyria. This is the second case report of an acute hepatic porphyria presenting with a subarachnoid haemorrhage. Acute transient hypertension during the attack of porphyria caused the rupture of an intracranial arterial aneurysm.

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