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Annals of Clinical Biochemistry

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This version was published on 1 November 2009
Ann Clin Biochem 2009;46:511-513
doi:10.1258/acb.2009.009037
© 2009 Association for Clinical Biochemistry

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Fetuin-A serum concentrations in healthy children

Marianne Wigger1,, Jan Schaible1,, Jutta Muscheites1, Guenther Kundt2, Dieter Haffner1 and Dagmar-Christiane Fischer1


1 Department of Pediatrics, University Children's Hospital Rostock; 2 Department of Medical Informatics and Biometry, University of Rostock, Germany


Corresponding author: Dagmar-Christiane Fischer, Department of Pediatrics, University Children's Hospital, Ernst-Heydemann-Str. 8, 18057 Rostock, Germany. Email: dagmar-christiane.fischer{at}med.uni-rostock.de

Background: Serum fetuin-A has been shown to be a strong risk marker for myocardial infarction/stroke in the general population, and has been associated with vascular calcifications in patients with chronic kidney disease. Although these issues are worthy of being addressed in children and adolescents as well, adequate age- and gender-related reference values are missing.

Method: Within a healthy paediatric population (n = 246), fetuin-A serum concentrations were determined (ELISA kit; Epitope Diagnostics, San Diego, CA, USA) essentially as described by the manufacturer. At the same time, serum protein and serum albumin were measured with established procedures (Beckman Coulter Inc., Krefeld, Germany). Subjects were stratified according to age (<1 yr [n = 25], ≥1 and <6 yr [n = 65], ≥6 and <12 yr [n = 66], ≥12 yr and <16 [n = 45] and ≥16 yr [n = 45]), and both genders were equally distributed within each age cohort.

Results: Within each age cohort, fetuin-A serum concentrations were normally distributed, independent of age and gender and the respective reference range (mean ± 1.96 SD) is 0.22–0.70 g/L (0.46 ± 0.24 g/L).

Conclusion: Fetuin-A serum concentrations are independent of age and gender in a healthy paediatric population and are well comparable with those determined in adults with the same assay.


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