Annals of Clinical Biochemistry > Volume 46, Number 6 > Pp. 520-522

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Case Reports

Unintentional silver intoxication following self-medication: an unusual case of corticobasal degeneration

Karolina M Stepien¹, Rob Morris², Sandy Brown¹, Andrew Taylor³ and Linda Morgan¹

¹ Clinical Pathology Department; ² Healthcare for Older People Department, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH; ³ School of Biological Sciences, University of Surrey, Guilford, Surrey GU2 7XH, UK

Corresponding author: Dr Karolina M Stepien, SpR, Chemical Pathology, Clinical Pathology Department, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK. Email: karolina.stepien{at}nuh.nhs.uk

Silver toxicity is a rare condition. The most notable feature is a grey-blue discoloration of the skin, argyria, although harmful effects on the liver and kidney may be seen in severe cases. Neurological symptoms are an unusual consequence of silver toxicity. So far no effective treatment has been described for this metal overdose. We report the case of a 75-year-old man who had a history of self-medication with colloidal silver and presented with myoclonic seizures.

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