Annals of Clinical Biochemistry > Volume 45, Number 6 > Pp. 567-570

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Median parameters for Down's syndrome screening should be calculated using a moving time-window method

T M Reynolds^1,2 and J Aldis²

¹ Clinical Chemistry Department, Queen's Hospital, Belvedere Road, Burton-on-Trent, Staffordshire DE13 0RB; ² Northern General Hospital, Sheffield S5 7A9, UK

View larger version (7K): [in this window] [in a new window]   Figure 1 Cusum plot showing effects of old and new mechanisms for calculation of medians. The three lines for the new median calculation method overlap each other on the Y = 0 axis. The Y-axis scale shows the cumulative sum of log10 multiples of the median, the X-axis is the count of sample number

 

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