Reference intervals for thyroid hormones in pregnant Chinese women

Ann Clin Biochem 2001;38:329-332
doi:10.1258/0004563011900830
© 2001 Association for Clinical Biochemistry

 

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Original Articles


N S Panesar,
C Y Li and
M S Rogers


Objective: To establish gestation-related reference intervalsfor thyroid hormones in a Chinese population.

Materials and methods: A prospective study with 343 healthy pregnant women (5-41 weeks) and 63 non-pregnant controls. Thyroid stimulating hormone (TSH), free thyroxine (T4) and tri-iodothyronine (T3) (and human chorionic gonadotrophin) were measured by immunoassays.The median, 2·5th and 97·5th percentiles at 4-weekintervals werecalculated. Data were also analysedfor significanttrends using ANOVA.

Results: Free T3 decreased during pregnancy, whereas free T4 initially increased, peaking between 9-13 weeks and then decreased, the decline becoming significant by week 21. TSH mirrored changes in free T4. Conclusion : The gestation-related reference intervalsfor thyroid hormones should alleviate the misinterpretationof thyroid function in pregnancy.

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