Free cortisol index as a surrogate marker for serum free cortisol

Ann Clin Biochem 2002;39:406-408
doi:10.1258/000456302760042182
© 2002 Association for Clinical Biochemistry

 

This Article
Right arrow

Full Text (PDF)

Right arrow
Alert me when this article is cited
Right arrow
Alert me if a correction is posted
Services
Right arrow
Email this article to a friend
Right arrow

Similar articles in this journal

Right arrow
Similar articles in PubMed
Right arrow
Alert me to new issues of the journal
Right arrow
Download to citation manager
Right arrow
Citing Articles
Right arrow
Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow
Articles by Le Roux, C. W
Right arrow
Articles by Wheeler, M. J
Right arrow Search for Related Content
PubMed
Right arrow
PubMed Citation
Social Bookmarking

What’s this?

Short Reports


Carel W Le Roux,
Sivajenani Sivakumaran,
Jamshid Alaghband-Zadeh,
Waljit Dhillo,
Wing May Kong and
Michael J Wheeler


Department of Chemical Pathology, Charing Cross Hospital, London W6 8RF, UK;
Department of Chemical Pathology, Charing Cross Hospital, London, W6 8RF, UK;
Department of Chemical Pathology, Charing Cross Hospital, London, W6 8RF, UK;
Department of Endocrinology, Charing Cross Hospital, London, W6 8RF, UK;
Department of Endocrinology, Charing Cross Hospital, London, W6 8RF, UK;
Department of Chemical Pathology St Thomas’ Hospital, London, UK


Background: The biologically active component of a hormone isthe unbound or free fraction. Changes in cortisol-binding proteincould give misleading results if only total cortisol is measuredfor the interpretation of dynamic function tests.

Methods: This study aimed to measure serum free cortisol usinga steady-state gel-filtration method and then to evaluate thecorrelation between the serum free cortisol and the free cortisolindex (FCI), defined as serum total cortisol/cortisol-bindingglobulin (CBG).

Results: Forty-eight serum samples from healthy volunteers undergoing a short Synacthen test were analysed for total cortisol, free cortisol and CBG. The FCI correlated well with a previously established, but more complex, calculation of serum free cortisol (R = 0·98, P <0·001) and with measured serum free cortisol (R = 0·90, P < 0·001).

Conclusion: Free cortisol index is a reliable and user-friendlymeasure of serum free cortisol.


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What’s this?






This article has been cited by other articles:


D. C. Lay Jr, H. G. Kattesh, J. E. Cunnick, M. J. Daniels, K. A. McMunn, M. J. Toscano, and M. P. Roberts
Prenatal stress effects on pig development and response to weaning
J Anim Sci,

June 1, 2008;
86(6):
1316 – 1324.

[Abstract]
[Full Text]
[PDF]