Analysis of serum angiotensin-converting enzyme

Ann Clin Biochem 2002;39:436-443
© 2002 Association for Clinical Biochemistry


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BR Muller

Department of Clinical Chemistry, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK

Serum angiotensin-converting enzyme (SACE) levels are influencedby genetic polymorphism. Interpretation of serum levels withthe appropriate genotypic reference range improves the diagnosticsensitivity of the assay for sarcoidosis. SACE assays are performedby a large number of routine clinical laboratories. However,there is no external quality assessment (EQA) for SACE otherthan an informal regional scheme. This showed analytical performanceof SACE assays to be poor, with a diversity of reference ranges,leading to widely disparate clinical classification of EQA samples.Genetic polymorphism combined with poor analytical performancesuggest that perhaps SACE assays should revert to being theprovince of specialized laboratories.

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