Changes in serum markers of bone turnover during normal pregnancy

Ann Clin Biochem 2003;40:508-513
doi:10.1258/000456303322326416
© 2003 Association for Clinical Biochemistry

This Article

Full Text (PDF)


Alert me when this article is cited

Alert me if a correction is posted
Services

Email this article to a friend

Similar articles in this journal


Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles
Citing Articles via Google Scholar
Google Scholar

Articles by Kaur, M.

Articles by Hosking, D. J
Search for Related Content
PubMed

PubMed Citation
Social Bookmarking

What’s this?

Original Articles


Malveen Kaur,
Ian M Godber,
Nigel Lawson,
Phillip N Baker,
Derek Pearson and
David J Hosking


Department of Obstetrics and Gynaecology and Division of Mineral Metabolism, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK;
Department of Clinical Chemistry, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK;
Department of Clinical Chemistry, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK;
Department of Obstetrics and Gynaecology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK;
Department of Medical Physics, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK;
Division of Mineral Metabolism, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK


Background: Maternal calcium homeostasis adapts during pregnancyto provide for the needs of the growing fetal skeleton. Wideselections of bone turnover markers are currently availableto assess the changes taking place; here, data are presentedon two serum-based markers.

Methods: The use of serum-based biochemical bone turnover markers during pregnancy was assessed in a cohort of 41 women recruited prior to conception. Serum N-terminal extension peptide of procollagen (P1NP) was used to monitor bone formation and serum β-crosslaps(S-CTX) used to assess resorption. Blood samples were measuredat five time points from a pre-conceptual baseline, throughpregnancy, to the final sample, which was taken within 1 weekof delivery.

Results: An initial decrease from the baseline in both P1NP and S-CTX was observed at 12 weeks; however, it is suggested that this may be due to the haemodilutional effect of pregnancy rather than a true change in bone turnover. Significant increases from the baseline of both analytes were observed by 36 weeks (P1NP, P = 0.013; S-CTX, P = 0.002), when the calcium demandsof the fetus are greatest.

Conclusions: This study illustrates the use of serum-based boneturnover markers to assess turnover during normal pregnancy,a time when ionizing radiation cannot be used to assess boneturnover.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What’s this?