False negative results in the Roche assay for HDL-cholesterol

Ann Clin Biochem 2003;40:572-575
doi:10.1258/000456303322326533
© 2003 Association for Clinical Biochemistry

This Article
Right arrow

Full Text (PDF)

Right arrow
Alert me when this article is cited
Right arrow
Alert me if a correction is posted
Services
Right arrow
Email this article to a friend
Right arrow

Similar articles in this journal

Right arrow
Similar articles in PubMed
Right arrow
Alert me to new issues of the journal
Right arrow
Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow
Articles by Bakker, A. J
Right arrow
Articles by Leemhuis, M. P
Right arrow Search for Related Content
PubMed
Right arrow
PubMed Citation
Social Bookmarking

What’s this?

Case Reports


Andries J Bakker,
Appie Zijlstra and
Marten P Leemhuis


Department of Clinical Chemistry, Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands;
Department of Clinical Chemistry, Stichting Klinisch Chemisch Laboratorium, Leeuwarden, The Netherlands;
Department of Internal Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands

Measurement of HDL-cholesterol is important in the risk evaluation of cardiovascular disease. Recently, we encountered a 61-year-old man with a negative result for HDL-cholesterol using the Roche assay. Further analysis revealed that this patient had a monoclonal Ig type IgM{kappa}, with an electrophoresis-based concentration of55.8 g/L, which apparently caused the negative result for HDL-cholesterol.Analysis of serum samples from other patients with monoclonalor polyclonal hypergammaglobulinaemia revealed that false negativeresults in the Roche assay for HDL-cholesterol may occur incidentally.Since negative results are detected easily in the laboratory,such patients do not pose a problem in daily practice. However,it is reasonable to suppose that false low results could alsobe caused by monoclonal as well as polyclonal Igs. Since suchfalse low results remain undetected, vascular risk estimatesconsequently are altered and unnecessary treatment might bestarted.


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What’s this?