Urinary 6β-hydroxycortisol/17-hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction

Ann Clin Biochem 2004;41:335-337
doi:10.1258/0004563041201527
© 2004 Royal Society of Medicine

This Article
Right arrow

Full Text (PDF)

Right arrow
Alert me when this article is cited
Right arrow
Alert me if a correction is posted
Services
Right arrow
Email this article to a friend
Right arrow

Similar articles in this journal

Right arrow
Similar articles in PubMed
Right arrow
Alert me to new issues of the journal
Right arrow
Download to citation manager
Right arrow
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow
Articles by Konishi, H.
Right arrow
Articles by Yamaji, A.
Right arrow Search for Related Content
PubMed
Right arrow
PubMed Citation
Social Bookmarking

What’s this?

Original Articles


Hiroki Konishi,
Kazuhiko Tanaka,
Tokuzo Minouchi and
Akira Yamaji


Department of Hospital Pharmacy, Shiga University of Medical Science, Otsu, Japan;
Department of Pediatrics, Nagahama Red-Cross Hospital, Nagahama, Japan and Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan;
Department of Hospital Pharmacy, Shiga University of Medical Science, Otsu, Japan;
Department of Hospital Pharmacy, Shiga University of Medical Science, Otsu, Japan


Background: The correlation between the urinary 6β-hydroxycortisol/17-hydroxycorticosteroids (6β-OHF/17-OHCS) ratio and the metabolic capacity of themost abundant form of hepatic cytochrome P450 (CYP3A4) afterinduction remains unclear.

Methods: Concentrations of 6β-OHF and 17-OHCS in spot urine specimens obtained from 61 epileptic children receiving continuous carbamazepine therapy were measured by high-performance liquid chromatography. The relationship between the urinary 6β-OHF/17-OHCSratio and the serum carbamazepine concentration, corrected fordose and body weight, was examined.

Results: Serum carbamazepine was inversely associated with the urinary 6β-OHF/17-OHCS ratio, and the hyperbolic relationship between the two parameters was statistically significant (P< 0.01).

Discussion: Carbamazepine is well known as a potent inducer and a substrate of hepatic CYP3A4. The present results suggest that measurement of the urinary 6βOHF/17-OHCS ratio ishelpful for assessing individuals’ hepatic CYP3A4 capacity afterenzyme induction.


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What’s this?