McArdle’s disease diagnosed following statin-induced myositis

Ann Clin Biochem 2004;41:338-340
doi:10.1258/0004563041201554
© 2004 Royal Society of Medicine

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Case Report


Callum Livingstone,
Said Al Riyami,
Peter Wilkins and
Gordon AA Ferns


Department of Clinical Biochemistry, Royal Surrey County Hospital, Guildford GU2 7XX, UK;
Department of Clinical Biochemistry, Royal Surrey County Hospital, Guildford GU2 7XX, UK;
Department of Neuropathology, Atkinson Morley’s Hospital, London, SW20 0NE, UK;
Department of Clinical Biochemistry, Royal Surrey County Hospital, Guildford GU2 7XX, UK

We describe the case of a 69-year-old man with a history ofmuscular symptoms dating back to his childhood; McArdle’s disease(glycogen-storage disease V) was diagnosed following an episodeof myositis in which a statin and physical exertion appear tohave been precipitating factors. This case demonstrates thatthe ischaemic lactate-ammonia test still has a place in screeningpatients with symptoms suggestive of McArdle’s disease and emphasizesthe importance of carrying out glycogen phosphorylase histochemistryon the skeletal muscle biopsy to confirm the diagnosis. In patientswho develop a raised plasma creatine kinase level or muscularsymptoms during lipid-lowering therapy, the clinician shouldbe alert to the possibility of an underlying myopathy.

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