Effects of menopause and tibolone on antioxidants in postmenopausal women

Ann Clin Biochem 2005;42:220-223
© 2005 Association for Clinical Biochemistry


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Original Articles

Perin Vural,
Cemil Akgül and
Mukaddes Canbaz

Department of Obstetrics and Gynaecology, Istanbul Medical Facility, Çapa 34093, Istanbul, Turkey;
Department of Biochemistry and Clinical Biochemistry, Istanbul Medical Facility, Çapa 34093, Istanbul, Turkey

Background: Oxidative stress has been implicated in the pathogenesisof ageing and menopause, and can arise through the increasedproduction of lipid peroxides and/or a deficiency of antioxidantdefence.

Aim: To investigate the effects of the menopause and tibolonetreatment (2.5 mg/day for six months) on plasma antioxidantsand lipid peroxidation.

Methods: Plasma concentrations of ascorbic acid, {alpha}-tocopherol,total thiol groups, caeruloplasmin, erythrocyte glutathione(GSH) and malondialdehyde (MDA) were measured in 24 postmenopausaland 24 premenopausal healthy women.

Results: Data analysis indicates a significant decrease in plasma ascorbic acid, {alpha}-tocopherol, total thiol groups, caeruloplasmin, erythrocyte GSH and a significant increase in lipid peroxides (expressed as MDA concentrations) in postmenopausal women. There was no significant difference between control and study groups in the mean plasma caeruloplasmin concentrations. It was found that there is a significant increase in {alpha}-tocopherol and significantdecrease in lipid peroxide concentrations in postmenopausalafter tibolone treatment.

Conclusions: The menopause is associated with an increase in oxidative stress and a decrease of some antioxidants, such as ascorbic acid, {alpha}-tocopherol, total thiols and erythrocyte GSH.Tibolone treatment leads to a decrease in concentrations ofplasma lipid peroxide, probably by stimulating direct and indirectmechanisms of tocopherol regeneration and increasing plasmaconcentrations of vitamin E. However, due to the relativelysmall numbers involved this study can be regarded as a pilot.Further studies performed on a larger scale are necessary toestablish the exact mechanisms of tibolone in inhibiting oxidativestress in postmenopausal women.

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