Ann Clin Biochem 2005;42:292-297
doi:10.1258/0004563054255597
© 2005 Association for Clinical Biochemistry

Original Articles

The effects of green tea ingestion over four weeks on atherosclerotic markers


Heungsup Sung,
Won-Ki Min,
Woochang Lee,
Sail Chun,
Hyosoon Park,
Yong-Wha Lee,
Seongsoo Jang and
Do-Hoon Lee


Department of Laboratory Medicine, Kangbuk Samsung Hospital and Sungkyunkwan University School of Medicine, Seoul, Korea;
Department of Laboratory Medicine, Asan Medical Center and University of College of Medicine, 388-1 Pungnap-dong, Songpa-Gu, Seoul 138-736, South Korea;
Department of Diagnostic Laboratory, National Cancer Center, Goyang, Gyeonggi, Korea


Background: The objective of this study was to evaluate the effects of green tea ingestion over four weeks on atherosclerotic biological markers.

Methods: After a one-week baseline period, 12 healthy male volunteers aged 28-42 years drank 600 mL of green tea dailyfor four weeks. Lipid profile, oxidized low-density lipoprotein (ox-LDL), total antioxidant capacity (TAC), C-reactive protein (CRP) and soluble cell adhesion molecules were measured at baseline and after two and four weeks ingestion of green tea.

Results: There was no significantchange in the concentrations of lipid profile, TAC, CRP, soluble intercellular adhesion molecule-1 (sICAM-1), or soluble E-selectin after ingestion of green tea. The levels of ox-LDL and soluble vascular cell adhesion molecule-1 (sVCAM-1) were significantly decreased after four weeks of green tea ingestion (Wilcoxon signed rank test, P=0.006).

Conclusions: The results of this study suggest an in vivo anti-oxidative effect for green tea and an influence of green tea on atherosclerotic biological markers. The effect of green tea seen on ox-LDL and sVCAM-1provides a potential mechanism for the cardiovascular benefits of regular ingestion of green tea.


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