Guidelines for the performance of the sweat test for the diagnosis of cystic fibrosis

Ann Clin Biochem 2007;44:25-34
doi:10.1258/000456307779596011
© 2007 Association for Clinical Biochemistry

 

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What’s this?

Review Article


Anne Green,
Jean Kirk and
The Guidelines Development Group


Department of Clinical Chemistry, Birmingham Children’s Hospital, Steelhouse Lane, Birmingham B4 6NH, UK;
Department of Paediatric Biochemistry, Royal Hospital for Sick Children, Sciennes Road, Edinburgh EH9 1LF, UK

A multidisciplinary group (representing various professionalbodies and supported by the Cystic Fibrosis Trust) has developedevidence-based guidelines for the performance of the sweat testin the UK. The guidelines cover patient information, subjectsuitability, sweat collection, sweat analysis, quality, interpretationof results, and responsibility for testing and training. Theguidelines were produced following a detailed literature searchby the process described by the Royal College of Paediatricsand Child Health (RCPCH), using the Scottish IntercollegiateGuidelines Network 1 (SIGN 1) criteria to grade the evidence.Recommendations are graded A, B, or C, depending on the levelof evidence. The grade B recommendations (there were no gradeA recommendations) were subsequently appraised and endorsedas part of the RCPCH process, according to Appraisal of Guidelinesfor Research and Evaluation in Europe (AGREE). The recommendationsare summarized in tabular form representing the final versionincorporating the comments from the appraisal process. Boththe appraisal comments and the full evidence base can be foundon www.rcpch.ac.uk/publications/clinical_docs.html. The fullguidelines can also be found on http://www.ukneqas.org.uk/guidelines.htm.


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