Oxidative and nitrosative stress in acute ischaemic stroke

Ann Clin Biochem 2007;44:43-47
© 2007 Association for Clinical Biochemistry


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Original Articles

Mehmet Senes,
Nuran Kazan,
Özlem Coskun,
Oguzhan Zengi,
Levent Inan and
Dogan Yücel

Department of Clinical Biochemistry, Ankara Education and Research Hospital, Cebeci, Ankara 06340, Turkey;
Department of Neurology, Ankara Education and Research Hospital, Cebeci, Ankara 06340, Turkey;
Department of Neurology, Ankara Education and Research Hospital, Cebeci, Ankara 06340, Turkey

Background: Increased nitric oxide (NO) production may resultin further brain damage via nitric oxide synthase uncouplingin patients with acute ischaemic stroke by increasing free radicalformation and oxidative stress. In this connection, we measurednitrite and nitrate (NO metabolites), ischaemia-modified albumin(IMA) and thiobarbituric acid-reactive substances (TBARS) inpatients with ischaemic stroke.

Methods: We studied 41 patients with ischaemic stroke (22 menand 19 women, aged 65-13 years) and 37 age- and sex-matchedcontrols (22 men and 15 women, aged 65-8 years). Blood sampleswere drawn within the first 24 h from the onset of symptomsin the patient group. Fasting morning samples were used in thecontrol group. Concentrations of nitrite and nitrate were determinedby Griess reagent; concentrations of IMA were determined bythe albumin cobalt-binding test; and concentrations of TBARSwere determined colorimetrically by thiobarbituric acid.

Results: Nitrate, IMA and TBARS concentrations were significantly increased compared with controls (P<0.005, P<0.001, and P=0.01, respectively).

Conclusions: Patients with acute ischaemic stroke exhibit abnormalitiesin a range of markers of increased nitrosative and oxidativestress. These abnormalities may contribute to greater braindamage in patients with acute ischaemic stress.

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