Fibrin monomer complex in normal pregnant women: a potential thrombotic marker in pregnancy

Ann Clin Biochem 2007;44:449-454
© 2007 Association for Clinical Biochemistry


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Original Articles

Hiroaki Onishi,
Kimiko Kaniyu,
Mitsutoshi Iwashita,
Asashi Tanaka and
Takashi Watanabe

Department of Obsterics/Gynecology, Kyorin University, Tokyo, Japan;
Department of Clinical Pathology, Hachiouji Medical Center, Tokyo Medical University, Tokyo, Japan;
Department of Laboratory Medicine, Kyorin University, Tokyo, Japan

Background: Pregnancy represents a major risk factor for deepvein thrombosis (DVT). Most coagulation/fibrinolysis markerscurrently utilized change during pregnancy, and therefore theycannot accurately evaluate thrombotic events in pregnancy becausethe rate of false positive results is high. Fibrin monomer complex(FMC) has recently become widely available for diagnosing DVT.The present study examined whether FMC is suitable for evaluatingthrombotic status in pregnancy.

Methods: Concentrations of FMC and other haemostatic markerswere investigated in 87 pregnant women without major complicationsat early, mid- or late pregnancy. FMC concentrations were alsomeasured in 127 normal non-pregnant women, and in one womanwho developed DVT after delivery.

Results: In normal pregnant women, FMC concentrations were unchangedduring early or mid-pregnancy and slightly elevated during latepregnancy. Concentrations were within reference range in mostcases, and none exceeded the cut-off value for DVT. In contrast,thrombin-antithrombin complex (TAT) and D-dimer (DD) concentrationswere significantly elevated in late pregnancy, and median valuesexceeded reference ranges. The DVT case displayed significantlyelevated FMC concentrations.

Conclusions: Changes in FMC concentrations during normal pregnancyare minimal compared with other haemostatic markers. Becausethe rate of false positivity is lower, FMC could be a potentialmarker of thrombotic status in pregnancy rather than TAT andDD.

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