Serum free light chains; the need to establish local reference intervals

Ann Clin Biochem 2007;44:512-515
doi:10.1258/000456307782268200
© 2007 Association for Clinical Biochemistry

 

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Original Articles


Rebecca J Pattenden,
Stephen Y Rogers and
Philip R Wenham


Department of Clinical Biochemistry, Fife Area Laboratories, Victoria Hospital, Kirkcaldy KY2 5AG, UK;
Department of Haematology, Fife Area Laboratories, Victoria Hospital, Kirkcaldy KY2 5AG, UK;
Department of Clinical Biochemistry, Fife Area Laboratories, Victoria Hospital, Kirkcaldy KY2 5AG, UK


Background: The purpose of this study was to compare The BindingSite serum free light chain assay on two analytical platforms;the Dade Behring BNII and the Olympus AU400. Reference intervalswere subsequently established on each analyser.

Methods: In total, 112 serum samples routinely submitted tothe laboratory for protein electrophoresis were used for thecomparison study. Reference interval data was generated from126 ostensibly healthy anonymous individuals.

Results: Serum free light chain results on the BNII and AU400analysers are not directly comparable. The BNII produces resultswhich are significantly higher than the AU400.

Conclusions: Laboratories using The Binding Site serum freelight chain assay are strongly advised to establish local referenceintervals.

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