Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients

Ann Clin Biochem 2007;44:549-556
doi:10.1258/000456307782268147
© 2007 Association for Clinical Biochemistry

 

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Original Articles


Kazuhiro Nakamura,
Takumi Takeuchi,
Ryunosuke Ohkawa,
Shigeo Okubo,
Hiromitsu Yokota,
Minoru Tozuka,
Junken Aoki,
Hiroyuki Arai,
Hitoshi Ikeda,
Noriko Ohshima,
Tadaichi Kitamura and
Yutaka Yatomi


Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan;
Department of Urology, Graduate School of Medicine, Tokyo, Japan;
Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan;
Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan;
Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan;
Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan;
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan; PRESTO, Japan Science and Technology Corporation, Tokyo, Japan;
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan;
Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;
Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan;
Department of Urology, Graduate School of Medicine, Tokyo, Japan;
Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan


Background: It is now established that the bioactive lipid lysophosphatidicacid (LPA) contributes to cancer initiation, progression andmetastasis, including those of prostate cancer. LPA is producedin the serum and plasma mainly by conversion from lysophospholipidsthrough the action of lysophospholipase D (lysoPLD), which isidentical to the soluble form of autotaxin (ATX) originallyisolated as a tumour cell motility-stimulating factor. In thisstudy, we evaluated the usefulness of lysoPLD/ATX activity asa diagnostic marker.

Methods: The serum lysoPLD activity, assessed by measuring cholineliberation from the substrate lysophosphatidylcholine, was measuredin patients with prostate cancer and compared with the concentrationsof prostate-specific antigen (PSA) and conventional nutritionalassessment markers.

Results: The serum lysoPLD activity in prostate cancer patientswas not statistically different from that in the controls. Consistentwith this, there was no correlation between the serum lysoPLDactivity and the serum PSA concentrations. However, the lysoPLD/ATXactivity did decrease after operation in the prostate cancerpatients and seemed to reflect the postoperative damage or thenutritional status.

Conclusions: We postulate that while the serum lysoPLD/ATX maynot be a marker of prostate cancer, it promises to instead bea new marker of nutritional status.


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