Urinary protein 1/Clara cell 16 concentrations and lung functions in male subjects with pneumoconiosis

Ann Clin Biochem 2007;44:560-562
doi:10.1258/000456307782268110
© 2007 Association for Clinical Biochemistry

 

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Kazuhiko Kotani,
Isao Kawabata,
Haosheng Mu,
Youichi Kurozawa and
Yoshihisa Itoh


Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan;
Department of Laboratory Medicine, Asahikawa Medical College, Asahikawa, Japan;
Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan;
Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan;
Department of Laboratory Medicine, Asahikawa Medical College, Asahikawa, Japan


Background: Protein 1 (P1)/Clara cell 16 kDa protein (CC16,previously named CC10), a potentially immunosuppressive proteinsecreted by non-ciliated cells of the tracheobronchial epithelium,has been found to be a new useful lung-specific biomarker inseveral pathological lung conditions. Particularly, urinaryP1 (uP1) may reflect the altered lung functions in pneumoconiosis.

Methods: We investigated the relationship between uP1 values and lung functions in 31 non-smoking pneumoconiotic males (mean age 73 years) with a history of dust exposure work in shipbuilding. The protein was measured using an originally prepared enzyme-linked immunosorbent assay system. The forced expiratory volume in 1 s % (FEV1.0%) and % vital capacity (%VC) were tested witha spirometer.

Results: The mean values of uP1 were 4.62 ± 4.82 (mean ± standard deviation) ng/mol creatinine. A univariable correlation test showed a significant positive correlation between uP1 and %VC (r = 0.356, P = 0.049). Also, a multiple regression analysis, when adjusted for age, disease duration, FEV1.0% and %VC, showed a significant correlation of uP1 with %VC (β = 0.467, P = 0.030).

Conclusion: The results suggest that a decreased uP1, corroboratedby a decreased %VC, may be the result of damage to secretorycells. Measurement of uP1 may become a possible index of fibroticchanges in pneumoconiosis.


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