A case study of mixed cryoglobulinaemia associated with peripheral neuropathy

Ann Clin Biochem 2007;44:566-569
doi:10.1258/000456307782268138
© 2007 Association for Clinical Biochemistry

 

This Article

Full Text (PDF)


Alert me when this article is cited

Alert me if a correction is posted
Services

Email this article to a friend

Similar articles in this journal


Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles
Citing Articles via Google Scholar
Google Scholar

Articles by Wheeler, R D

Articles by Sheldon, J
Search for Related Content
PubMed

PubMed Citation
Social Bookmarking

What’s this?

Case Reports


R D Wheeler,
H Sharma,
M Groves,
D Wren and
J Sheldon


Protein Reference Unit, St George’s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK;
Centre for Clinical Neuroscience, St George’s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK;
Division of Neuropathology, Institute of Neurology UCL, Queen Square, London, UK;
Centre for Clinical Neuroscience, St George’s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK;
Protein Reference Unit, St George’s Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK

The clinical diagnosis of mixed cryoglobulinaemia is difficultdue to heterogeneity in presentation. Symptoms include the classicaltriad of purpura, arthralgia and weakness, with one or moreother organs involved. We discuss a case of cryoglobulinaemiathat presented with sensory motor neuropathy and with featuresof mononeuritis multiplex syndrome, but which lacked other classicalfeatures. Laboratory testing revealed a profile typical of mixedcryoglobulins: immunoglobulin M (IgM) paraprotein, low fourthcarbon (C4) and positive rheumatoid factor. Subsequent investigationsfailed to reveal an underlying infectious or neoplastic cause.This case demonstrates the need to include cryoglobulinaemiain the differential diagnosis for peripheral neuropathy, andthe critical importance of using the correct collection procedureto isolate cryoglobulins.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What’s this?