A case with transient increases in serum S100A8/A9 levels implying acute inflammatory responses after pancreatic islet transplantation

Ann Clin Biochem 2007;44:570-572
doi:10.1258/000456307782268156
© 2007 Association for Clinical Biochemistry

 

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Case Reports


Masaki Ikemoto,
Shinichi Matsumoto,
Hiroto Egawa,
Teru Okitsu,
Yasuhiro Iwanaga,
Shinji Umemoto,
Hiroshi Itoh,
Hiroshi Murayama and
Masatoshi Fujita


Department of Laboratory Science, School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan;
Department of Transplantation Unit, Kyoto University Hospital, Kyoto 606-8507, Japan;
Department of Transplantation Unit, Kyoto University Hospital, Kyoto 606-8507, Japan;
Department of Transplantation Unit, Kyoto University Hospital, Kyoto 606-8507, Japan;
Department of Transplantation Unit, Kyoto University Hospital, Kyoto 606-8507, Japan;
Department of Transplantation Unit, Kyoto University Hospital, Kyoto 606-8507, Japan;
Department of Laboratory Science, School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan;
Diagnostic Division, Immunological Laboratory, Yamasa Shoyu Co., Ltd, Choshi, Chiba 288-0056, Japan;
Department of Laboratory Science, School of Health Sciences, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan

We investigated a patient with type 1 diabetes mellitus undergoingpancreatic islets transplantation. In this patient, we evaluatedthe clinical usefulness of serial measurement of serum S100A8/A9complex levels for detecting acute inflammatory responses associatedwith rejection of transplanted pancreatic islets. The serumS100A8/A9 complex was a more sensitive marker for acute inflammationassociated with islet transplant rejection than the serum C-reactiveprotein. Thus, the serial measurement of the serum S100A8/A9complex concentration is useful for monitoring the patientswith pancreatic islet transplantation.

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