Extent of bilirubin interference with Beckman creatinine methods

Ann Clin Biochem 2008;45:91-92
© 2008 Association for Clinical Biochemistry


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Goce Dimeski ,
Brett McWhinney,
Brock Jones,
Rebecca Mason and
Andrew Carter

Department of Chemical Pathology, Queensland Health Pathology Service (QHPS), Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia

Corresponding author: Goce Dimeski. Email: Goce_Dimeski{at}health.qld.gov.au

Background: The aim of the study was to determine the extent of bilirubininterference on two different Beckman–Coulter creatininemethods used on the CX5 PRO/DxC 600 and the DxC 800 systems,respectively.

Methods: The Beckman methods were compared with a high-performance liquid chromatography (HPLC) method using 104 patient samples with creatinine concentrations <133 µmol/L and bilirubin concentrations of between 30 and 802 µmol/L.

Results: The linear regression analysis calculations expressing the relationship between bilirubin concentration and the observed difference between the Beckman and HPLC creatinine methods are: DxC800 creatinine M (modular or cup) method: r2 0.217, slope –0.023 and intercept 6.43; and DxC600 method: r2 0.7324, slope –0.0882and intercept 12.01.

Conclusions: There is significantly greater interference by bilirubin onthe CX5 PRO/DxC 600 method, which can lead to inaccuracy inthe calculation of the estimated glomerular filtration rateby the Modification of Diet in Renal Disease equation.

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