Intraindividual variation in serum thyroid hormones, parathyroid hormone and insulin-like growth factor-1

Ann Clin Biochem 2008;45:167-169
© 2008 Association for Clinical Biochemistry


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Original Article

T Ankrah-Tetteh,
S Wijeratne and
R Swaminathan 

Department of Chemical Pathology, St Thomas’ Hospital, 5th Floor, North Wing, Lambeth Palace Road, London SE1 7EH, UK

Corresponding author: Prof R Swaminathan. Email: r.swaminathan{at}

Background: Biological variation of an analyte is an important determinantof its usefulness. Intraindividual variation in serum thyroidhormones, parathyroid hormone (PTH) and insulin-like growthfactor-1 (IGF-1) in healthy subjects was determined in thisstudy.

Methods: Blood samples were taken at weekly intervals for six weeks from10 healthy subjects and analysed for serum thyroid-stimulatinghormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3),PTH and IGF-1.

Results: Intraindividual variations for serum FT4 and FT3 were <5.0%,IGF-1 9.4% and TSH and PTH 25.1% and 25.9%, respectively. Indexof individuality was lowest for FT4 (0.42) and FT3 (0.38), andhighest for PTH (1.09).

Conclusion: Intraindividual variation for FT4, FT3 and IGF-1 are low.

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