Balance of transforming growth factor-β1 and platelet-derived growth factor-BB is associated with kidney allograft rejection

Ann Clin Biochem 2008;45:213-214
doi:10.1258/acb.2007.007155
© 2008 Association for Clinical Biochemistry

 

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Ubaldo Pozzetto 1 ,
Damiano Abeni 2,
Franco Citterio 3,
Marco Castagneto 3,
Maurizio C Capogrossi 2 and
Antonio Facchiano 2


1 Centro Shock, IASI–CNR, Largo Gemelli 8, 00168 Rome;
2 Istituto Dermopatico dell’Immacolata, IDI-IRCCS;
3 Dipartimento di Chirurgia, Università Cattolica Sacro Cuore, Rome, Italy


Corresponding author: Dr Ubaldo Pozzetto. Email: aldopozzetto{at}hotmail.com


Background: About 50% of kidney-transplant patients undergo organ rejectionwithin 10 years. Chronic allograft nephropathy (CAN) representsthe dominant cause of kidney transplant failure and accountsfor 50–80% of graft loss in long-term surviving patients.CAN pathogenesis is multifactorial and not-completely elucidated;several reports indicate TGF-β1 and platelet-derived growthfactor (PDGF)-BB expression in CAN suggesting a possible roleof these factors in the allograft arteriosclerosis and graftfailure.

Methods: We investigated the plasma expression concentrations of humangrowth factors with enzyme-linked immunosorbent assays and appropriatestatistical analysis.

Results: We present evidences showing statistically significant associationof CAN with a specific balance between TGF Beat1 and PDGF-BBplasma concentrations, in 129 kidney-transplant patients and15 healthy controls. Odds ratios were computed to correlateexpression-levels with CAN occurrence.

Conclusion: We believe these data may suggest a novel non-invasive methodto identify early molecular markers of graft deterioration.

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