Hypokalaemic paralysis precipitated by distal renal tubular acidosis secondary to Sjögren’s syndrome

Ann Clin Biochem 2008;45:221-225
© 2008 Association for Clinical Biochemistry


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Case Report

D M Comer 1 ,
A G Droogan 2,
I S Young 3 and
A P Maxwell 4

1 Senior House Officer, General Medicine, Craigavon Area Hospital Group Trust, Craigavon BT63 5QQ, Northern Ireland;
2 Consultant Neurologist;
3 Consultant Chemical Pathologist, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland;
4 Consultant Nephrologist, Belfast City Hospital, Belfast BT9 7AB, Northern Ireland

Corresponding author: Dr D M Comer. Email: dcomer{at}doctors.org.uk

A 43-year-old woman presented with a sudden onset of hypokalaemicparalysis requiring intubation and ventilatory support. Subsequentbiochemical and clinical assessments established a diagnosisof distal renal tubular acidosis (RTA) in association with underlyingSjögren’s syndrome as the aetiology of her profound hypokalaemia.Distal RTA is rare, but Sjögren’s syndrome is one of themore common causes in adults and should be considered in thedifferential diagnosis of patients who present with hypokalaemicmuscular paralysis.

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