A paediatric case of macro aspartate aminotransferase

Ann Clin Biochem 2008;45:323-324
© 2008 Association for Clinical Biochemistry


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Case Reports

Robert Lord1,
Michael Fahie-Wilson2 and
Sanjay Suri3

1 Department of Clinical Biochemistry, Rotherham NHS Foundation Trust, Rotherham S60 2UD, UK;
2 Biochemistry Department, Southend Hospital, Prittlewell Chase, Westcliff on Sea, Essex SS0 0RY, UK;
3 Department of Child Health, Rotherham NHS Foundation Trust, Rotherham S60 2UD, UK

Corresponding author: Dr R Lord. Email: robert.lord{at}rothgen.nhs.uk

Macroenzymes are enzymes in plasma that have a higher molecularmass than the corresponding enzyme normally present under (patho)physiological conditions. Macro species have been describedfor most routinely measured enzymes, but with only a few reportsof macro species with aspartate aminotransferase (AST), andin particular very few reports in children and adolescents.Routine biochemical analysis in a 15-year-old girl presentingwith lower back pain revealed an isolated raised AST as partof a liver function test profile. Polyethylene glycol precipitationand gel filtration chromatography showed this to be a macrospecies.

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M. Fahie-Wilson and D. Halsall
Polyethylene glycol precipitation: proceed with care
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May 1, 2008;
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