A rare cause of Cushing’s syndrome demonstrates analytical discrepancies between the Roche E170 and Bayer Centaur testosterone assays

Ann Clin Biochem 2008;45:328-330
doi:10.1258/acb.2007.007166
© 2008 Association for Clinical Biochemistry

 

This Article

Full Text

Full Text (PDF)


Alert me when this article is cited

Alert me if a correction is posted
Services

Email this article to a friend

Similar articles in this journal


Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles
Citing Articles via Google Scholar
Google Scholar

Articles by Hancock, S.

Articles by Stephens, J. W
Search for Related Content
PubMed

PubMed Citation
Social Bookmarking

What’s this?

Case Reports


Sian Hancock1,
Rachel A Still1,
Andrew M Fielding1,
John F Doran1 and
Jeffrey W Stephens2


1 Chemical Pathology Services;
2 Department of Medicine, Swansea NHS Trust, Morriston Hospital, Swansea SA6 6NL, UK


Corresponding author: Dr Sian Hancock. Email: sian.hancock{at}swansea-tr.wales.nhs.uk

The initial biochemical investigations of a female patient withsuspected Cushing’s syndrome revealed abnormal endocrine results,including a marked elevation of serum testosterone. Overnightand low-dose dexamethasone suppression tests confirmed the diagnosisof Cushing’s syndrome. Imaging investigations revealed an appearancecompatible with adrenocortical carcinoma with metastases inthe lungs and liver. This tumour is a rare cause of Cushing’ssyndrome. Two different automated testosterone immunoassayswere used during the investigation of this patient, and analyticaldiscrepancies in the patient’s testosterone results were found.The two assays used, as well as potential causes of the differencein results will be discussed.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What’s this?