The association of advanced glycation end-products with glutathione status

Ann Clin Biochem 2008;45:369-374
© 2008 Association for Clinical Biochemistry


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Original Articles

Emel Sahin1,
Ayse Yesim Göçmen1,
Hüseyin Koçak2,
Murat Tuncer2 and
Saadet Gümüs1

1 Faculty of Medicine, Department of Biochemistry;
2 Faculty of Medicine, Department of Nephrology, Akdeniz University, 07070 Antalya, Turkey

Corresponding author: Prof Saadet Gümüslü. Email: sgumuslu{at}

Background: The aim of this study was to investigate oxidative stress withregard to the concentrations of advanced oxidation protein products(AOPP), advanced glycation end-products (AGEs), pentosidine,glycated albumin, reduced glutathione (GSH) and oxidized glutathione(GSSG), glutathione redox ratios and thiobarbituric acid-reactivesubstances (TBARS) in non-diabetic patients undergoing continuousambulatory peritoneal dialysis (CAPD).

Methods: The study group consisted of 52 non-diabetic CAPD patients and34 healthy controls. AOPP, AGEs, pentosidine and glycated albuminwere measured in plasma, whereas GSH, GSSG and TBARS concentrationswere measured in erythrocytes of both patients and controls.

Results: All parameters were found to be significantly increased, exceptthe glutathione redox ratio, which was found to be decreasedin patients undergoing CAPD. Multiple regression analysis showedthat AGEs were the only independent predictor of glutathioneredox ratio, whereas AGEs, glycated albumin and TBARS were eachfound to be independent predictors of albumin concentration.

Conclusion: Our results support the hypothesis that oxidative stress andAOPPs/AGEs constitute important risk factors in CAPD patients.The negative relationship between albumin and both AGEs andTBARS suggests that the decrease in albumin may contribute tothe increased advanced glycation and lipid peroxidation. Thenegative relationship between glutathione redox ratio and AGEssuggests that late products of glycation play an important rolein the development of oxidative stress observed in patientsundergoing peritoneal dialysis treatment.

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