The association of advanced glycation end-products with glutathione status

Ann Clin Biochem 2008;45:369-374
doi:10.1258/acb.2007.007186
© 2008 Association for Clinical Biochemistry

 

This Article
Right arrow
Full Text
Right arrow

Full Text (PDF)

Right arrow
Alert me when this article is cited
Right arrow
Alert me if a correction is posted
Services
Right arrow
Email this article to a friend
Right arrow

Similar articles in this journal

Right arrow

Similar articles in Web of Science

Right arrow
Similar articles in PubMed
Right arrow
Alert me to new issues of the journal
Right arrow
Download to citation manager
Right arrow
Citing Articles
Right arrow

Citing Articles via Web of Science (1)

Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow
Articles by Sahin, E.
Right arrow
Articles by Gümüslü, S.
Right arrow Search for Related Content
PubMed
Right arrow
PubMed Citation
Social Bookmarking

What’s this?

Original Articles


Emel Sahin1,
Ayse Yesim Göçmen1,
Hüseyin Koçak2,
Murat Tuncer2 and
Saadet Gümüs1


1 Faculty of Medicine, Department of Biochemistry;
2 Faculty of Medicine, Department of Nephrology, Akdeniz University, 07070 Antalya, Turkey


Corresponding author: Prof Saadet Gümüslü. Email: sgumuslu{at}akdeniz.edu.tr


Background: The aim of this study was to investigate oxidative stress withregard to the concentrations of advanced oxidation protein products(AOPP), advanced glycation end-products (AGEs), pentosidine,glycated albumin, reduced glutathione (GSH) and oxidized glutathione(GSSG), glutathione redox ratios and thiobarbituric acid-reactivesubstances (TBARS) in non-diabetic patients undergoing continuousambulatory peritoneal dialysis (CAPD).

Methods: The study group consisted of 52 non-diabetic CAPD patients and34 healthy controls. AOPP, AGEs, pentosidine and glycated albuminwere measured in plasma, whereas GSH, GSSG and TBARS concentrationswere measured in erythrocytes of both patients and controls.

Results: All parameters were found to be significantly increased, exceptthe glutathione redox ratio, which was found to be decreasedin patients undergoing CAPD. Multiple regression analysis showedthat AGEs were the only independent predictor of glutathioneredox ratio, whereas AGEs, glycated albumin and TBARS were eachfound to be independent predictors of albumin concentration.

Conclusion: Our results support the hypothesis that oxidative stress andAOPPs/AGEs constitute important risk factors in CAPD patients.The negative relationship between albumin and both AGEs andTBARS suggests that the decrease in albumin may contribute tothe increased advanced glycation and lipid peroxidation. Thenegative relationship between glutathione redox ratio and AGEssuggests that late products of glycation play an important rolein the development of oxidative stress observed in patientsundergoing peritoneal dialysis treatment.


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What’s this?