Protein S-100 is present in extracerebral fluids before and after cardiac surgery in children

Ann Clin Biochem 2008;45:409-412
© 2008 Association for Clinical Biochemistry

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Original Articles

Nicole Nagdyman1,
Peter Ewert1,
Katharina Schmitt1,
Michael Hübler2,
Brigitte Stiller3,
Christian Müller4 and
Felix Berger5

1 Department of Congenital Heart Disease;
2 Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum;
3 Childrens University Hospital, 79106 Freiburg, Germany;
4 Institute of Laboratory Medicine;
5 Department of Pediatric Cardiology, Charité-Universitätsmedizin, 13353 Berlin, Germany

Corresponding author: Dr Nicole Nagdyman. Email: nagdyman{at}

Background: Protein S-100 is found in extracerebral sources. The aim ofour study was to examine the content of protein S-100 in nativepericardial fluid as well as in postoperative extracerebralfluids after cardiac surgery in children.

Methods: We conducted a prospective study in 90 children measuring proteinS-100 concentration in pericardial fluid directly after openingthe pericardial sac before starting with cardiac surgery. Postoperatively,we examined pleural, peritoneal and pericardial fluid.

Results: Pericardial fluid sampled directly after opening the pericardial sac has a protein S-100 content of 3.2 (1.3–5.4) µg/L. Postoperatively, protein S-100 content was 0.89 (0.56–2.6) µg/L in pleural effusion, 0.14 (0.1–1.1) µg/Lin peritoneal fluid and 2.75 (2.2–24.4) µg/L inpericardial fluid. The protein S-100 concentration in pericardialfluid before and after cardiac operation did not differ significantly.Pericardial protein S-100 concentrations were significantlyhigher than pleural and peritoneal protein S-100 concentrations.

Conclusions: Protein S-100 is present in extracerebral fluids before andafter cardiac surgery in children. The time point of fluid withdrawalafter the operation did not influence the protein S-100 concentration.

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