Low adiponectin state is associated with metabolic abnormalities in obese children, particularly depending on apolipoprotein E phenotype

Ann Clin Biochem 2008;45:496-503
© 2008 Association for Clinical Biochemistry



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Original Articles

Elfi Wardaningsih1,
Takashi Miida2,
Utako Seino1,
Yuriko Fueki1,
Masayuki Ito1,
Keisuke Nagasaki3,
Toru Kikuchi3,
Makoto Uchiyama3,
Satoshi Hirayama4,
Osamu Hanyu4,
Kazunori Miyake2 and
Masahiko Okada1

1 Division of Clinical Preventive Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1-757, Chuo-ku, Niigata 951-8510;
2 Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421;
3 Division of Pediatrics;
4 Division of Endocrinology and Metabolism, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1-757, Chuo-ku, Niigata 951-8510, Japan

Corresponding author: Dr Takashi Miida. Email: tmiida{at}juntendo.ac.jp

Background: Adiponectin links obesity with insulin resistance, which causesvarious metabolic abnormalities including dyslipidaemia. ApolipoproteinE (apoE) phenotypes also affect lipoprotein profiles. We aimedto determine whether low adiponectin concentrations are associatedwith insulin resistance and downstream metabolic abnormalitiesin obese children.

Methods: We measured fasting concentrations of lipids, apoE, glucose, insulin and adiponectin, as well as anthropometric parameters, in 191 obese children aged 6–15 years. ApoE phenotypes were determined by isoelectric focusing. Boys (n = 79) and girls (n = 39) with apoE3/3 were classified into tertiles accordingto their adiponectin concentrations. Metabolic parameters, werecompared among these three groups in boys and girls separately.

Results: The low adiponectin groups had higher median homeostasis model assessment of insulin resistance (HOMA-IR) than the middle and high adiponectin groups in both boys [5.3 (low) versus 3.1 (middle; P < 0.05) and 3.5 (high; P < 0.05)] and girls [5.0 (low) versus 4.4 (middle) and 3.0 (high; P < 0.05)]. However, onlyboys who were in the low adiponectin group exhibited significantlyhigher concentrations of blood pressure, triglycerides, LDL-cholesterol,and remnant-like particle-cholesterol, and lower concentrationsof HDL-cholesterol compared with the middle or high adiponectingroups.

Conclusion: Low adiponectin concentration is associated with insulin resistancein obese children. Furthermore, decreased adiponectin with E3/3exhibited more prominent downstream metabolic abnormalitiesin obese boys than in obese girls.

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