The relationship between estimated glomerular filtration rate and thyroid function: an observational study

Ann Clin Biochem 2008;45:515-517
© 2008 Association for Clinical Biochemistry



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Short Reports

Anne Woodward,
Steven McCann and
Mohammad Al-Jubouri

Department of Clinical Biochemistry, Whiston Hospital, Warrington Road, Merseyside L35 5DR, UK

Corresponding author: Mr Steven McCann. Email: mccann.sjm{at}

Background: Estimated glomerular filtration rate (eGFR) is now routinelyreported by most National Health Service laboratories. Thereare many limitations when interpreting eGFR: thyroid dysfunctionis not widely recognized as being one of these.

Methods: We extracted from the pathology computer system results of allpatients with hypothyroidism and hyperthyroidism who also hadserum creatinine measured. We also extracted creatinine dataon euthyroid patients. eGFR was calculated using the simplifiedModification of Diet in Renal Disease Study equation.

Results: The median eGFRs of the hypothyroid, euthyroid and hyperthyroid patients were 64, 77 and 107 mL/min/1.73 m2, respectively; all groups were significantly different from each other (P <0.001).

Conclusion: Thyroid dysfunction is associated with significant alterationsin eGFR and actual GFR.

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