Superoxide dismutase, copper and zinc concentrations in platelet-rich plasma of pneumonia patients

This version was published on 1 March 2009

Ann Clin Biochem 2009;46:123-128
doi:10.1258/acb.2008.008178
© 2009 Association for Clinical Biochemistry

 

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Original Articles


R Lakaj1,
S Dodig2,
I epelak3 and
I Kuzman1


1 Univeristy Hospital for Infectious Diseases;
2 Srebrnjak Children’s Hospital, Reference Center for Clinical Pediatric Allergology of the Ministry of Health and Welfare;
3 Department of Medical Biochemistry and Hematology, School of Pharmacy and Biochemistry, University of Zagreb, 1000 Zagreb, Croatia


Corresponding author: Renata Lakaj. Email: rlaskaj{at}net4u.hr


Background: The aim of this study was to analyse platelet superoxide dismutase(SOD) activities (total SOD, manganese SOD and copper zinc SOD)and copper (Cu) and zinc (Zn) concentrations during the courseof community-acquired pneumonia (CAP), and to compare them betweenpatients with normal platelet count and those who have developedreactive thrombocytosis (RT).

Methods: Platelet count, SOD activities and Cu and Zn concentrationsin platelet-rich plasma were measured in patients with CAP onadmission and at discharge.

Results: Post-therapeutic platelet count increased significantly fromthe value recorded on admission. By the end of treatment, 42%of patients developed RT. All platelet SOD activities as wellas Cu concentration were significantly lower in CAP patientsthan in control subjects. The initial Zn concentration was greaterin CAP patients compared with controls and showed a decreaseat discharge. On admission, there was no difference in all SODactivities between either subgroup with normal platelet countor subgroup with RT. At discharge all SOD activities were significantlylower in patients with RT. Also, catalytic activities of thoseenzymes were significantly lower in both subgroups in comparisonwith the initial values. Post-therapeutic Cu value was lowerin patients with RT in comparison with patients having normalplatelet count. Zn concentration decreased significantly atdischarge when compared with the initial values only in patientswith RT.

Conclusion: The pattern of changes might be indicative of a certain roleof platelets in antioxidant response during treatment in CAPpatients.

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