Ischaemia-modified albumin in dilated cardiomyopathy

Ann Clin Biochem 2009;46:241-243
© 2009 Association for Clinical Biochemistry


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Original Articles

Eftihia Sbarouni,
Panagiota Georgiadou,
Maria Koutelou,
Ioannis Sklavainas,
Demosthenes Panagiotakos and
Vassilis Voudris

2nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens 176 74, Greece

Corresponding author: Eftihia Sbarouni, 2nd Department of Cardiology, Onassis Cardiac Surgery Center, 356 Syngrou Avenue, Athens 176 74, Greece. Email: esbarouni{at}

Background: Biomarkers of myocardial necrosis may be increased in patientswith chronic heart failure. We investigated whether ischaemia-modifiedalbumin (IMA), a marker of ischaemia, is also elevated in patientswith compensated heart failure, due to dilated cardiomyopathy(DCM).

Methods: We studied 42 patients with DCM and an equal number of age-matchednormal volunteers. We assessed IMA serum levels with the albumincobalt binding test.

Results: IMA was 89.9 ± 13.1 (71–117) KU/L in the patient group and 93.9 ± 9.9 (76–122) KU/L in the control group, with no significant difference between the two (P = 0.11). However, IMA differed significantly according to the New York Heart Association classification (P = 0.003) and was negatively correlated with the left ventricular ejection fraction (r = –0.40, P = 0.014).

Conclusions: We conclude that IMA, a marker of ischaemia, does not differin patients with clinically stable DCM compared with normalsubjects, but varies significantly in relation to the severityof the disease.

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