Postprandial bone turnover is independent of calories above 250 kcal

This version was published on 1 July 2010

Ann Clin Biochem 2010;47:318-320
© 2010 Association for Clinical Biochemistry


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Original Articles

Manal O Elnenaei1,
Rebecca Musto1,
Jamshid Alaghband-Zadeh1,
Caje Moniz1 and
Carel W Le Roux1,2

1 Clinical Biochemistry Department, King’s College Hospital NHS Foundation Trust, London, SE5 9RS;
2 Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, London, WI2 0HS, UK

Corresponding author: Carel W Le Roux. Email: c.leroux{at}

Background: The mechanisms causing bone turnover after food intake havenot yet been elucidated. Several gut hormones are secreted inthe postprandial phase, proportional to meal calorie content,and possibly one or more of these could influence bone turnover.The aim of this study was to investigate bone turnover in proportionto graded-calorie and fixed calcium containing meals.

Methods: A group of healthy volunteers were given six meals with caloriesvarying from 250 to 3000 kcal on different occasions. All themeals contained 500 mg of calcium. C-telopeptide type I collagen(CTX) was measured before and 180 min after each meal.

Results: All meals significantly reduced CTX between 35.8 ± 5.6%and 44.8 ± 3.8%. No significant difference in CTX washowever apparent for the different calorie containing meals.Observed differences suggest a trend to greater CTX suppressionwith lower protein and higher fat content of meals.

Conclusion: Changes in CTX are not proportional to calorie contents whenthe meals contain 500 mg of calcium. Further studies shouldnow determine whether patients with increased bone resorptionwould benefit from multiple small meals to slow down the rateof bone loss.

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