The value of serum free light chains in a case of Waldenstrom’s macroglobulinaemia that produces a type I cryoglobulinaemia

This version was published on 1 November 2009

Ann Clin Biochem 2009;46:531-532
© 2009 Association for Clinical Biochemistry


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Case Reports

Rebecca J Pattenden1,
Kerri L Davidson2 and
Philip R Wenham1

1 Department of Clinical Biochemistry;
2 Department of Haematology, Fife Area Laboratories, Victoria Hospital, Kirkcaldy KY2 5AG, UK

Corresponding author: Rebecca J Pattenden. Email: rebecca.pattenden{at}

Lymphoplasmacytic lymphoma (Waldenstrom’s macroglobulinaemia)is a low-grade small-cell lymphoma that produces monoclonalIgM. Usually, clinical features are related to growth of thetumour and include weakness and fatigue, an increased bleedingtendency, and neurological and visual disturbances. We presenta case of lymphoplasmacytic lymphoma with type I cryoglobulinaemiathat presented with clinical symptoms associated with hyperviscositysyndrome. Quantitation of the paraprotein was not possible usingconventional serum protein electrophoresis due to the high serumviscosity, and therefore monitoring was carried out using serialserum free light chain measurements.

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