Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns

This version was published on 1 January 2010

Ann Clin Biochem 2010;47:29-34
doi:10.1258/acb.2009.009080
© 2010 Association for Clinical Biochemistry

 

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Original Articles


Gaya W Katulanda1,2,
Prasad Katulanda3,4,
A I Adler5,
S R Peiris3,
I Draisey1,
S Wijeratne6,
R Sheriff3,
D R Matthews4 and
Brian Shine1


1 Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK;
2 Department of Pathology, National Hospital of Sri Lanka;
3 Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka;
4 Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK;
5 Institute of Metabolic Sciences, Addenbrooke’s Hospital, Cambridge, UK;
6 Endocrine and Reproductive Laboratory, University of Colombo, Colombo, Sri Lanka


Corresponding author: Dr Brian Shine. Email: brian.shine{at}orh.nhs.uk


Background: Apolipoproteins B (apoB) and AI (apoAI) are strong predictorsof cardiovascular disease (CVD). We describe apolipoproteindistributions and their associations with lipids and diabetessubtype in diabetic young adult South Asians.

Methods: In 995 subjects with diabetes, we measured fasting total cholesterol(TC), high-density lipoprotein cholesterol (HDLC), triglycerides(TG), apoB and apoAI, glycosylated haemoglobin (HbA1c) and glutamicacid decarboxylase antibodies (GADA). Low-density lipoproteincholesterol (LDLC) and non-HDLC (NHDLC) were calculated. Wecompared values in subjects aged 15–50 y from the UnitedStates National Health and Nutrition Examination Survey (NHANES).

Results: Median age and duration of diabetes were 38 (range 14–45)and 4 (0–24) y. Men had significantly higher TC, TG, NHDLC,TC/HDLC, apoB/AI and NHDLC/apoB, and lower apoAI than women.Compared with the reference group, patients with type 1 diabeteshad lower TG, apoB:apoAI and HDLC:apoAI, and higher HDLC andapoAI. Patients with type 2 diabetes had higher TG, TC, LDLC,NHDLC, TC:HDL, apoB, apoAI and apoB:apoAI, and lower HDLC, LDLC:apoBand HDLC:apoAI. Among patients with type 2 diabetes, 54% hadhigh apoB (>1.2 g/L) and 33% also had high TG (>1.5 mmol/L).Measures of obesity (body mass index and waist circumference)were weakly correlated with lipid and apoprotein parameters,suggesting a modest contribution to dyslipidaemia.

Conclusions: A large proportion of young adult Sri Lankan patients with type2 diabetes has a low LDLC:apoB and high apoB and/or TG, suggestingthat these patients are at increased risk of CVD.


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