Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns

This version was published on 1 January 2010

Ann Clin Biochem 2010;47:29-34
© 2010 Association for Clinical Biochemistry


This Article
Right arrow
Figures Only
Right arrow
Full Text
Right arrow

Full Text (PDF)

Right arrow
All Versions of this Article:



most recent

Right arrow
Alert me when this article is cited
Right arrow
Alert me if a correction is posted
Right arrow
Email this article to a friend
Right arrow

Similar articles in this journal

Right arrow
Similar articles in PubMed
Right arrow
Alert me to new issues of the journal
Right arrow
Download to citation manager
Right arrow
Citing Articles
Right arrow
Citing Articles via HighWire
Google Scholar
Right arrow
Articles by Katulanda, G. W
Right arrow
Articles by Shine, B.
Right arrow
PubMed Citation
Social Bookmarking

What’s this?

Original Articles

Gaya W Katulanda1,2,
Prasad Katulanda3,4,
A I Adler5,
S R Peiris3,
I Draisey1,
S Wijeratne6,
R Sheriff3,
D R Matthews4 and
Brian Shine1

1 Department of Clinical Biochemistry, John Radcliffe Hospital, Oxford, UK;
2 Department of Pathology, National Hospital of Sri Lanka;
3 Diabetes Research Unit, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka;
4 Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK;
5 Institute of Metabolic Sciences, Addenbrooke’s Hospital, Cambridge, UK;
6 Endocrine and Reproductive Laboratory, University of Colombo, Colombo, Sri Lanka

Corresponding author: Dr Brian Shine. Email: brian.shine{at}orh.nhs.uk

Background: Apolipoproteins B (apoB) and AI (apoAI) are strong predictorsof cardiovascular disease (CVD). We describe apolipoproteindistributions and their associations with lipids and diabetessubtype in diabetic young adult South Asians.

Methods: In 995 subjects with diabetes, we measured fasting total cholesterol(TC), high-density lipoprotein cholesterol (HDLC), triglycerides(TG), apoB and apoAI, glycosylated haemoglobin (HbA1c) and glutamicacid decarboxylase antibodies (GADA). Low-density lipoproteincholesterol (LDLC) and non-HDLC (NHDLC) were calculated. Wecompared values in subjects aged 15–50 y from the UnitedStates National Health and Nutrition Examination Survey (NHANES).

Results: Median age and duration of diabetes were 38 (range 14–45)and 4 (0–24) y. Men had significantly higher TC, TG, NHDLC,TC/HDLC, apoB/AI and NHDLC/apoB, and lower apoAI than women.Compared with the reference group, patients with type 1 diabeteshad lower TG, apoB:apoAI and HDLC:apoAI, and higher HDLC andapoAI. Patients with type 2 diabetes had higher TG, TC, LDLC,NHDLC, TC:HDL, apoB, apoAI and apoB:apoAI, and lower HDLC, LDLC:apoBand HDLC:apoAI. Among patients with type 2 diabetes, 54% hadhigh apoB (>1.2 g/L) and 33% also had high TG (>1.5 mmol/L).Measures of obesity (body mass index and waist circumference)were weakly correlated with lipid and apoprotein parameters,suggesting a modest contribution to dyslipidaemia.

Conclusions: A large proportion of young adult Sri Lankan patients with type2 diabetes has a low LDLC:apoB and high apoB and/or TG, suggestingthat these patients are at increased risk of CVD.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What’s this?

This article has been cited by other articles:

Home page Ann Clin BiochemHome page

A. D Sniderman
Apolipoprotein B, Diabetes and Medical Consensus
Ann Clin Biochem,

January 1, 2010;
2 – 3.

[Full Text]