Glycated albumin levels are higher relative to glycated haemoglobin levels in gastrectomized subjects

This version was published on 1 January 2010

Ann Clin Biochem 2010;47:39-43
doi:10.1258/acb.2009.009127
© 2010 Association for Clinical Biochemistry

 

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Original Articles


Masafumi Koga1,
Jun Murai1,
Hiroshi Saito1,
Mikio Mukai1,
Soeko Matsumoto2 and
Soji Kasayama3


1 Department of Internal Medicine;
2 Department of Clinical Laboratory, Kinki Central Hospital, Hyogo;
3 Department of Medicine, Nissay Hospital, Osaka, Japan


Corresponding author: Masafumi Koga, Department of Internal Medicine, Kinki Central Hospital, Kuruma-zuka 3-1, Itami, Hyogo 664-8533, Japan. Email: koga_m{at}kich.itami.hyogo.jp


Background: In gastrectomized subjects, oral glucose tolerance test often shows marked hyperglycaemia (oxyhyperglycaemia) after glucose loading. Because serum glycated albumin (GA) has been shown to better reflect postprandial and maximum plasma glucose levels, we investigated whether or not the clinical significance of serum GA and glycated haemoglobin (HbA1C) in non-diabetic gastrectomizedsubjects differs.

Methods: During health examinations, 62 non-diabetic subjects with ahistory of gastrectomy and 87 non-diabetic control subjectswere selected in the present study. Body mass index (BMI) inthe gastrectomy group was significantly lower than in the controlgroup.

Results: Fasting plasma glucose levels were significantly lower in the gastrectomized subjects than in the control subjects. Although both HbA1C and serum GA were significantly higher in the gastrectomized subjects, there was a significant difference in GA/HbA1C ratiobetween the gastrectomized subjects and the control subjects.BMI-adjusted serum GA, based on our previous finding of inverseinfluence of BMI on serum GA, was also significantly higherin the gastrectomized subjects than in the controls.

Conclusions: Serum GA is higher relative to HbA1C in gastrectomized subjects. This suggests that serum GA may be a better marker than HbA1Cfor glycaemic excursion in these subjects.


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