Postpartum increase of serum thioredoxin concentrations and the relation to CD8 lymphocytes

This version was published on 1 January 2010

Ann Clin Biochem 2010;47:62-66
© 2010 Association for Clinical Biochemistry


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Original Articles

Shoko Kuroda1,
Mikio Watanabe1,
Tomoko Santo1,
Yu Shimizuishi1,
Toru Takano2,
Yoh Hidaka2,
Tadashi Kimura3 and
Yoshinori Iwatani1

1 Department of Biomedical Informatics, Division of Health Sciences;
2 Department of Laboratory Medicine;
3 Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan

Corresponding author: Yoshinori Iwatani, Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, 1–7, Yamadaoka, Suita, Osaka, Japan. Email: iwatani{at}

Background: There are few data on oxidative stresses during and after pregnancy,although aggravation of autoimmune disease is implicated inoxidative stress and occurs frequently in the postpartum period.Thioredoxin (TRX) is a stress-inducible protein, and is usedas a good biomarker for oxidative stress. To clarify the changesin the levels of oxidative stress during and after pregnancy,we examined serum TRX levels and the numbers of lymphocyte subsets.

Methods: We measured serum TRX levels by enzyme-linked immunosorbentassay (ELISA), and neutrophils, lymphocytes, and CD4 and CD8lymphocytes by flow cytometry in peripheral blood from 88 healthypregnant women, 26 just after delivery women, 77 healthy postpartumwomen and 19 healthy non-pregnant women.

Results: The serum levels of TRX did not change during pregnancy, butincreased in four, seven and 10 months postpartum. Serum TRXlevels were correlated with the percentages of neutrophils innormal non-pregnant women and women one month postpartum, andwith those of CD8 lymphocytes in early pregnant women and womenone and four months postpartum.

Conclusions: Oxidative stress increased in the postpartum period, and thelevels at one and four months postpartum were related to CD8lymphocytes.

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